Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
نویسندگان
چکیده
Beben Benyamin1,2, Tonu Esko3,4, Janina S. Ried5, Aparna Radhakrishnan6, Sita H. Vermeulen7,8, Michela Traglia9,10, Martin Gögele11, Denise Anderson12, Linda Broer13,14, Clara Podmore15, Jiańan Luan15, Zoltan Kutalik16,17, Serena Sanna18, Peter van der Meer19, Toshiko Tanaka20, Fudi Wang21, Harm-Jan Westra22, Lude Franke22, Evelin Mihailov3,23, Lili Milani3, Jonas Hälldin3, Juliane Winkelmann24,25,26,27, Thomas Meitinger26,28, Joachim Thiery29,30, Annette Peters31,32, Melanie Waldenberger31,32, Augusto Rendon6,33,34, Jennifer Jolley6,33, Jennifer Sambrook6,33, Lambertus A. Kiemeney7,35, Fred C. Sweep36, Cinzia F. Sala37, Christine Schwienbacher11, Irene Pichler11, Jennie Hui38,39, Ayse Demirkan13,40, Aaron Isaacs13,41, Najaf Amin13, Maristella Steri18, Gérard Waeber42, Niek Verweij19, Joseph E. Powell1,43, Dale R. Nyholt2, Andrew C. Heath44, Pamela A.F. Madden44, Peter M. Visscher1,43, Margaret J. Wright2, Grant W. Montgomery2, Nicholas G. Martin2, Dena Hernandez45, Stefania Bandinelli46, Pim van der Harst19,47,48, Manuela Uda18, Peter Vollenweider42, Robert A. Scott15, Claudia Langenberg15, Nicholas J. Wareham15, InterAct Consortiumw, Cornelia van Duijn13,41,49, John Beilby38,39, Peter P. Pramstaller11,50, Andrew A. Hicks11, Willem H. Ouwehand6,33, Konrad Oexle28, Christian Gieger5,31,32, Andres Metspalu3, Clara Camaschella9,51, Daniela Toniolo9, Dorine W. Swinkels36 & John B. Whitfield2
منابع مشابه
Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P<5 × 10(-8)) loci, some including known iron-related genes (HFE, SLC...
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